If you're like the majority of League of Legends players, your face turns stony and confused when
So what does this have to do with League of Legends? Well, everything, to be honest. There are
(Keep in mind that DPI scales based on the resolution of your monitor. For the purposes of this conversation, we're going to assume that you have
Low DPI (1-1200 DPI)
Do you specialize in skillshot champions that require a surfeit of accuracy and precision in order to be effective? Then a low DPI setting might be for you. Professional FPS players tend to love a low DPI setting as it allows for more precise mouse movements, which directly results in higher accuracy. Of equal importance is the fact that it's very easy for your body to remember the exaggerated movements that low DPI setups demand of you, which means your muscle memory will prove far more effective than someone who plays on a very high DPI setting, where the movements are too small for the body to process properly.
However, low DPI has one gigantic flaw in League of Legends. It makes scrolling about the map extremely difficult. While low DPI is perfect for the nuanced movements required to, say, aim a Blitzcrank hook just where you want it, it's terrible for big sweeping movements, such as the ones that you use to look around the map. Low DPI players will mostly be forced to click on the minimap in order to look around, as scrolling to the sides is simply too impractical. Just keep in mind that if you decide to go with a low DPI setting you'll likely be less effective on roaming champions like Taliyah or on champions that require constant attention across the map, like Shen. If you don't play a lot of skil shot champions, that tradeoff is almost certainly not worth it.
Medium DPI (1201- 3000 DPI)
There's not a whole lot to say about medium DPI settings. This is where a lot of gaming mice start right out of the box, and the lower end of this range tends to be the default for many gamers. It offers a nice combination of speed and precision that makes it perfect for certain champions that need to both fire off skill shots and thus need the precision of low DPI, but also need to move around a lot and thus benefit from higher DPI settings as well. Ahri fits quite nicely into this category, as she's a bit too mobile to make a low DPI setting feasible on her, but she also demands perfect accuracy in order to be effective.
Basically, if you don't need that perfect precision that low DPI offers (which, unless you're a Xerath main, you probably don't), nor the twitchy control that a high DPI setting offers, then you should probably start in this range. At the end of the day, the most important thing is finding a DPI setting that works best for you, and if you don't need anything that the two extremes offer, then starting in the middle is a pretty wise decision, though I would personally recommend you stick to the lower end of this range, in that case.
High DPI (3000+ DPI)
On the total
If you manage to stick with it, though, high DPI is arguably the most effective setting for a game like League of Legends. There's a reason that the first professional gamers to adopt settings such as these were Starcraft players. It's absolutely perfect for games that are forgiving about precision but demand extremely fast reactions. Most League of Legends champions fit that bill exactly, so a high DPI player that has mastered their mouse settings is something to be feared. On top of that, high DPI tends to fatigue the wrist less than other settings, simply because it uses far less drastic movements, so it also enables longer play sessions, though whether that's a plus side or not is probably something your doctor would have a thing or two to say about.
At the end of the day, though, remember that DPI is all about finding a setting that works best for you. Figure out what your playstyle is, choose a DPI setting that's appropriate, and master it. That's the way to win, not choosing something just because it sounds the best in a void.